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Geranylgeranyl Diphosphate Synthase 1 (GGPS1)

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GGPPS1; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase

Geranylgeranyl Diphosphate Synthase 1 (GGPS1)
CCC C498
HGNC 4249
MGI 1341724
PubMed 10101267
RGD 1359680
UniProt O95749
Wiki GGPS1

Geranylgeranyl pyrophosphate synthetase is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The deduced protein shows 16% identity with farnesyl diphosphate synthase and contains 3 N-glycosylation sites as well as the 5 domains common to trans-prenyltransferases. expression in heart, skeletal muscle, and testis and the shorter transcript as the major species in these tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC498Hu01 Recombinant Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC498Hu01 Polyclonal Antibody to Geranylgeranyl Diphosphate Synthase 1 (GGPS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC498Mu01 Recombinant Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC498Mu01 Polyclonal Antibody to Geranylgeranyl Diphosphate Synthase 1 (GGPS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Geranylgeranyl Diphosphate Synthase 1 (GGPS1) ELISA Kit Customized Service Offer
  1. "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression."J. Lipid Res. 39:1731-1739(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human geranylgeranyl diphosphate synthase. cDNA cloning and expression."J. Biol. Chem. 274:5888-5894(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Study on isolation of a geranylgeranyl pyrophosphate (GGPP) synthase cDNA and its expression -- development of a new assay system of gene functions."Proc. Jpn. Conf. Biochem. Lipids 41:293-296(1999)
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human."Biochim. Biophys. Acta 1437:333-340(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding."J. Biol. Chem. 281:22004-22012(2006) [PubMed] [Europe PMC] [Abstract]