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Glucagon Receptor (GCGR)

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GGR

Glucagon Receptor (GCGR)
CCC C510
HGNC 4192
MGI 99572
PubMed 21631939
RGD 2669
UniProt P47871
Wiki GCGR
The glucagon receptor is a 62 kDa peptide that is activated by glucagon and is a member of the G-protein coupled family of receptors, coupled to Gs. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC510Hu01 Recombinant Glucagon Receptor (GCGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC510Hu01 Polyclonal Antibody to Glucagon Receptor (GCGR) WB; IHC; ICC; IP.
LAC510Hu71 Biotin-Linked Polyclonal Antibody to Glucagon Receptor (GCGR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Glucagon Receptor (GCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucagon Receptor (GCGR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucagon Receptor (GCGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucagon Receptor (GCGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucagon Receptor (GCGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucagon Receptor (GCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucagon Receptor (GCGR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucagon Receptor (GCGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucagon Receptor (GCGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucagon Receptor (GCGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucagon Receptor (GCGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucagon Receptor (GCGR) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a human glucagon receptor."Biochem. Biophys. Res. Commun. 198:328-334(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization."Gene 140:203-209(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Localization of the glucagon receptor gene to human chromosome band 17q25."Genomics 20:327-328(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Role of the glucagon receptor COOH-terminal domain in glucagon-mediated signaling and receptor internalization."Diabetes 46:1400-1405(1997) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype."J. Biol. Chem. 281:2306-2316(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular basis for negative regulation of the glucagon receptor."Proc. Natl. Acad. Sci. U.S.A. 109:14393-14398(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the human glucagon class B G-protein-coupled receptor."Nature 499:444-449(2013) [PubMed] [Europe PMC] [Abstract]
  10. "A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus."Diabetologia 38:983-985(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor."Pancreas 38:941-946(2009) [PubMed] [Europe PMC] [Abstract]