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Homeodomain Interacting Protein Kinase 1 (HIPK1)

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Myak; Nbak2; Nuclear body-associated kinase 2

Homeodomain Interacting Protein Kinase 1 (HIPK1)
CCC C526
HGNC 19006
MGI 1314873
PubMed 16537918
RGD 1304941
UniProt Q86Z02
Wiki HIPK1
Homeodomain-interacting protein kinase 1 is an enzyme belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Northern blot analysis detected expression in all mouse and human tissues examined. RNA dot-blot analysis of human tissues detected expression in all adult and fetal tissues. Immunolocalization of Hipk1 in mouse fibroblasts detected punctate nuclear staining. Hipk1 also localized throughout the nucleus and was excluded only from nucleoli. In addition, there was a diffuse cytoplasmic staining.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC526Hu01 Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC526Hu01 Polyclonal Antibody to Homeodomain Interacting Protein Kinase 1 (HIPK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeodomain Interacting Protein Kinase 1 (HIPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeodomain Interacting Protein Kinase 1 (HIPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeodomain Interacting Protein Kinase 1 (HIPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeodomain Interacting Protein Kinase 1 (HIPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeodomain Interacting Protein Kinase 1 (HIPK1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
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  5. "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization."J. Biol. Chem. 278:47245-47252(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity."Mol. Cell. Biol. 23:950-960(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."Proc. Natl. Acad. Sci. U.S.A. 100:5431-5436(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation."J. Biol. Chem. 280:15061-15070(2005) [PubMed] [Europe PMC] [Abstract]
  9. "DJ-1 interacts with HIPK1 and affects H2O2-induced cell death."Free Radic. Res. 40:155-165(2006) [PubMed] [Europe PMC] [Abstract]
  10. "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis."Cell Death Differ. 15:739-750(2008) [PubMed] [Europe PMC] [Abstract]
  11. "HIPK1 interacts with c-Myb and modulates its activity through phosphorylation."Biochem. Biophys. Res. Commun. 388:150-154(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]