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Histocompatibility 13, Minor (HM13)

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H13; IMP1; IMPAS; PSENL3; PSL3; SPP; Signal Peptide Peptidase Beta; Presenilin-Like Protein 3; Intramembrane Protease

Histocompatibility 13, Minor (HM13)
CCC C530
HGNC 16435
MGI 95886
PubMed 9354467
RGD 1308946
UniProt Q8TCT9
Wiki HM13
Minor histocompatibility antigen H13 is a protein, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein.
The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histocompatibility 13, Minor (HM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histocompatibility 13, Minor (HM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histocompatibility 13, Minor (HM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histocompatibility 13, Minor (HM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility 13, Minor (HM13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histocompatibility 13, Minor (HM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histocompatibility 13, Minor (HM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histocompatibility 13, Minor (HM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histocompatibility 13, Minor (HM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility 13, Minor (HM13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histocompatibility 13, Minor (HM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histocompatibility 13, Minor (HM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histocompatibility 13, Minor (HM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histocompatibility 13, Minor (HM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility 13, Minor (HM13) ELISA Kit Customized Service Offer
  1. "Identification of signal peptide peptidase, a presenilin-type aspartic protease."Science 296:2215-2218(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development."Gene Expr. Patterns 3:685-691(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Novel class of polytopic proteins with domains associated with putative protease activity."Biochemistry (Mosc.) 67:826-834(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Cell-surface expression of a new splice variant of the mouse signal peptide peptidase."Biochim. Biophys. Acta 1759:159-165(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes."J. Immunol. 167:6441-6446(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets."EMBO J. 21:3980-3988(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein."FEBS Lett. 557:185-192(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins."J. Biol. Chem. 279:50790-50798(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER."J. Cell Biol. 186:685-692(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u."EMBO J. 33:2492-2506(2014) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]