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Histatin 3 (HTN3)

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HIS2; HTN2; HTN5; Hst; PB; Histidine-rich protein 3; Basic histidine-rich protein

Histatin 3 (HTN3)
CCC C535
HGNC 5284
PubMed 10471575
UniProt P15516
Wiki HTN3
The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity. Histatin 1 and histatin 2 are major wound-closing factors in human saliva.Histatin-3 1/24 (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, histatin-3 1/24 is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC535Hu01 Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC535Hu01 Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
MAC535Hu21 Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
MAC535Hu23 Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
MAC535Hu22 Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
Assay Kits SEC535Hu ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of human submandibular histatins."Arch. Oral Biol. 35:137-143(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family."Mol. Biol. Evol. 10:497-511(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant."Hum. Mutat. 4:12-19(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans."J. Biol. Chem. 263:7472-7477(1988) [PubMed] [Europe PMC] [Abstract]
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  9. "A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway."J. Biol. Chem. 279:41436-41443(2004) [PubMed] [Europe PMC] [Abstract]
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  11. "Zinc and copper bind to unique sites of histatin 5."FEBS Lett. 491:76-80(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease."Infect. Immun. 69:1402-1408(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5."J. Biol. Chem. 278:28553-28561(2003) [PubMed] [Europe PMC] [Abstract]
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  16. "Salivary peptidomics."Expert Rev. Proteomics 7:709-721(2010) [PubMed] [Europe PMC] [Abstract]