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Intestinal Cell Kinase (ICK)

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LCK2; MRK; Serine/threonine-protein kinase ICK; Laryngeal cancer kinase 2; MAK-related kinase

Intestinal Cell Kinase (ICK)
CCC C539
HGNC 21219
MGI 1934157
PubMed 19696144
RGD 71050
UniProt Q9UPZ9
Wiki ICK_(gene
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. Serine/threonine-protein kinase ICK is an enzyme protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. ICK expression in all tissues examined, with highest expression in brain, spinal cord, testis, and ovary. Among specific brain regions, very high expression was detected in corpus callosum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC539Hu01 Recombinant Intestinal Cell Kinase (ICK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC539Hu01 Polyclonal Antibody to Intestinal Cell Kinase (ICK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Intestinal Cell Kinase (ICK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intestinal Cell Kinase (ICK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC539Mu01 Recombinant Intestinal Cell Kinase (ICK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC539Mu01 Polyclonal Antibody to Intestinal Cell Kinase (ICK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Intestinal Cell Kinase (ICK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intestinal Cell Kinase (ICK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC539Ra01 Recombinant Intestinal Cell Kinase (ICK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC539Ra01 Polyclonal Antibody to Intestinal Cell Kinase (ICK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Intestinal Cell Kinase (ICK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intestinal Cell Kinase (ICK) ELISA Kit Customized Service Offer
  1. "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases."J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] [Abstract].
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  6. "ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport."EMBO J. 33:1227-1242(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling."Proc. Natl. Acad. Sci. U.S.A. 111:8541-8546(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems."Am. J. Hum. Genet. 84:134-147(2009) [PubMed] [Europe PMC] [Abstract]