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Intersectin 1 (ITSN1)

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ITSN; SH3D1A; SH3P17; SH3 Domain Protein; Src Homology 3 Domain-Containing Protein; Intersectin 1 Short Form Variant 3

Intersectin 1 (ITSN1)
CCC C548
HGNC 6183
MGI 1338069
PubMed 21876463
RGD 2935
UniProt Q15811
Wiki ITSN1
Intersectin-1 is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.Ubiquitous in adult and fetal tissues, except isoform 1 which is expressed almost exclusively in the brain. Highly expressed in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested. Expressed at lower levels in thymus, blood, lung, liver and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intersectin 1 (ITSN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intersectin 1 (ITSN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intersectin 1 (ITSN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intersectin 1 (ITSN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 1 (ITSN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC548Mu01 Recombinant Intersectin 1 (ITSN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Intersectin 1 (ITSN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intersectin 1 (ITSN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intersectin 1 (ITSN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 1 (ITSN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC548Ra01 Recombinant Intersectin 1 (ITSN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC548Ra01 Polyclonal Antibody to Intersectin 1 (ITSN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Intersectin 1 (ITSN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 1 (ITSN1) ELISA Kit Customized Service Offer
  1. "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon."Genomics 53:369-376(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome."Eur. J. Hum. Genet. 7:704-712(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Structural diversity and differential expression of novel human intersectin 1 isoforms."Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1."Gene 485:120-129(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
  9. "The human intersectin genes and their spliced variants are differentially expressed."Biochim. Biophys. Acta 1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2."Cytogenet. Cell Genet. 78:213-215(1997) [PubMed] [Europe PMC] [Abstract]
  11. "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."J. Biol. Chem. 277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "FCHo proteins are nucleators of clathrin-mediated endocytosis."Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors."Nat. Struct. Biol. 9:468-475(2002) [PubMed] [Europe PMC] [Abstract]