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Katanin P60 Subunit A 1 (KATNA1)

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Katanin p60 ATPase-containing subunit A1

Katanin P60 Subunit A 1 (KATNA1)
CCC C552
HGNC 6216
MGI 1344353
PubMed 11732186
RGD 1303062
UniProt O75449
Wiki KATNA1
Katanin p60 ATPase-containing subunit A1 is an enzyme encoded by the KATNA1 gene.Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase.
Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC552Hu01 Recombinant Katanin P60 Subunit A 1 (KATNA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC552Hu01 Polyclonal Antibody to Katanin P60 Subunit A 1 (KATNA1) WB; IHC
Assay Kits n/a CLIA Kit for Katanin P60 Subunit A 1 (KATNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Katanin P60 Subunit A 1 (KATNA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC552Mu01 Recombinant Katanin P60 Subunit A 1 (KATNA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC552Mu01 Polyclonal Antibody to Katanin P60 Subunit A 1 (KATNA1) WB,IHC
Assay Kits n/a CLIA Kit for Katanin P60 Subunit A 1 (KATNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Katanin P60 Subunit A 1 (KATNA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Katanin P60 Subunit A 1 (KATNA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Katanin P60 Subunit A 1 (KATNA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Katanin P60 Subunit A 1 (KATNA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Katanin P60 Subunit A 1 (KATNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Katanin P60 Subunit A 1 (KATNA1) ELISA Kit Customized Service Offer
  1. "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs."Mol. Biol. Cell 9:1847-1861(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin."J. Cell Sci. 113:1623-1633(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis."J. Cell Sci. 115:1083-1092(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells."J. Biol. Chem. 284:11663-11675(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase."Nat. Cell Biol. 11:409-419(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]