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Karyopherin Alpha 3 (KPNa3)

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KPN-A3; IPOA4; Qip2; SRP1gamma; SRP4; hSRP1; Importin Alpha 4; Importin alpha Q2

Karyopherin Alpha 3 (KPNa3)
CCC C556
HGNC 6396
MGI 1100863
PubMed 15882913
RGD 1311339
UniProt O00505
Wiki KPNA3
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs).
KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC556Hu01 Recombinant Karyopherin Alpha 3 (KPNa3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC556Hu01 Polyclonal Antibody to Karyopherin Alpha 3 (KPNa3) WB; IHC
Assay Kits n/a CLIA Kit for Karyopherin Alpha 3 (KPNa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 3 (KPNa3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 3 (KPNa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 3 (KPNa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 3 (KPNa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 3 (KPNa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 3 (KPNa3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 3 (KPNa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 3 (KPNa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 3 (KPNa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 3 (KPNa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 3 (KPNa3) ELISA Kit Customized Service Offer
  1. "Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1."Cytogenet. Cell Genet. 76:87-93(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family."FEBS Lett. 417:104-108(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor."Proc. Natl. Acad. Sci. U.S.A. 95:582-587(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein."J. Biol. Chem. 278:28193-28200(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication."J. Virol. 84:8650-8663(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]