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Kisspeptin 1 (KISS1)

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Metastin; KiSS-1 Metastasis-Suppressor

Kisspeptin 1 (KISS1)
CCC C559
HGNC 6341
MGI 2663985
PubMed 16932310
RGD 727850
UniProt Q15726
Wiki Kisspeptin
Kisspeptin is a G-protein coupled receptor ligand for GPR54. Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. It is recently become clear that kisspeptin-GPR54 signaling has an important role in initiating GnRH secretion at puberty, the extent of which is an area of ongoing research.Kisspeptin is a metastasis suppressor of melanomas and breast cancers without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC559Hu01 Recombinant Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
CPC559Hu21 OVA Conjugated Kisspeptin 1 (KISS1) Immunogen; SDS-PAGE; WB.
Antibodies PAC559Hu01 Polyclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
MAC559Hu22 Monoclonal Antibody to Kisspeptin 1 (KISS1) WB,IHC
PAC559Hu08 Polyclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
MAC559Hu21 Monoclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
Assay Kits SEC559Hu ELISA Kit for Kisspeptin 1 (KISS1) Enzyme-linked immunosorbent assay for Antigen Detection.
CEC559Hu ELISA Kit for Kisspeptin 1 (KISS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC559Mu01 Recombinant Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC559Mu02 Recombinant Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC559Mu01 Polyclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
PAC559Mu02 Polyclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
Assay Kits CEC559Mu ELISA Kit for Kisspeptin 1 (KISS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC559Ra01 Recombinant Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
EPC559Ra61 Eukaryotic Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
EPC559Ra62 Eukaryotic Kisspeptin 1 (KISS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC559Ra01 Polyclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
MAC559Ra21 Monoclonal Antibody to Kisspeptin 1 (KISS1) WB; IHC; ICC; IP.
Assay Kits CEC559Ra ELISA Kit for Kisspeptin 1 (KISS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kisspeptin 1 (KISS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kisspeptin 1 (KISS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kisspeptin 1 (KISS1) Polyclonal Antibody Customized Service Offer
Assay Kits CEC559Bo ELISA Kit for Kisspeptin 1 (KISS1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene."J. Natl. Cancer Inst. 88:1731-1737(1996) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Natl. Cancer Inst. 89:1549-1549(1997)
  3. "Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)."Genomics 54:145-148(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor." Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1."Cancer Res. 57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display."Int. J. Cancer 71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract]
  11. "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Metastin suppresses the motility and growth of CHO cells transfected with its receptor."Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract]
  13. "KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation."J. Biol. Chem. 276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23."Cancer Res. 61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome."Am. J. Pathol. 162:609-617(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans."J. Clin. Endocrinol. Metab. 88:914-919(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma."Int. J. Cancer 111:868-872(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat."Biochem. Biophys. Res. Commun. 320:383-388(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis."J. Neuroendocrinol. 16:850-858(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Inactivating KISS1 mutation and hypogonadotropic hypogonadism."N. Engl. J. Med. 366:629-635(2012) [PubMed] [Europe PMC] [Abstract]