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Eukaryotic translation initiation factor 2D (EIF2D)

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HCA56; LGTN; Hepatocellular carcinoma-associated antigen 56; Ligatin

Eukaryotic translation initiation factor 2D (EIF2D)
CCC C565
HGNC 6583
MGI 109342
PubMed 3805022
RGD 1561765
UniProt P41214
Ligatin is a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.Trafficking receptor for phosphoglycoproteins. Localizes phosphoglycoproteins within endosomes and at the cell periphery where they participate in specific metabolic processes as well as intercellular adhesion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC565Hu01 Recombinant Eukaryotic translation initiation factor 2D (EIF2D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC565Hu01 Polyclonal Antibody to Eukaryotic translation initiation factor 2D (EIF2D) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Eukaryotic translation initiation factor 2D (EIF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic translation initiation factor 2D (EIF2D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC565Mu01 Recombinant Eukaryotic translation initiation factor 2D (EIF2D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC565Mu01 Polyclonal Antibody to Eukaryotic translation initiation factor 2D (EIF2D) WB,IHC
Assay Kits n/a CLIA Kit for Eukaryotic translation initiation factor 2D (EIF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic translation initiation factor 2D (EIF2D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC565Ra01 Recombinant Eukaryotic translation initiation factor 2D (EIF2D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC565Ra01 Polyclonal Antibody to Eukaryotic translation initiation factor 2D (EIF2D) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Eukaryotic translation initiation factor 2D (EIF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic translation initiation factor 2D (EIF2D) ELISA Kit Customized Service Offer
  1. "GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor."J. Biol. Chem. 285:26779-26787(2010) [PubMed] [Europe PMC] [Abstract]
  2. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of the cDNA for ligatin."J. Cell Sci. 93:227-232(1989) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."Genes Dev. 24:1787-1801(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]