≡

Lymphocyte Specific Protein 1 (LSP1)

[Edit]

WP34; pp52; 47 kDa actin-binding protein; 52 kDa phosphoprotein; Lymphocyte-specific antigen WP34

Lymphocyte Specific Protein 1 (LSP1)
CCC C573
HGNC 6707
MGI 96832
PubMed 11261799
RGD 1306133
UniProt P33241
Wiki LSP1
Lymphocyte-specific protein 1 is an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.
May et al. (1993) and others used various cDNA cloning strategies to identify genes preferentially expressed in B lymphocytes. One gene, variously named LSP1 and pp52, exhibited a number of properties supporting a possible role in B-cell signaling pathways. The gene codes for a 52-kD phosphoprotein expressed only in transformed and untransformed B cells, thymocytes, and untransformed T-cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphocyte Specific Protein 1 (LSP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphocyte Specific Protein 1 (LSP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein 1 (LSP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein 1 (LSP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC573Mu01 Recombinant Lymphocyte Specific Protein 1 (LSP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC573Mu01 Polyclonal Antibody to Lymphocyte Specific Protein 1 (LSP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein 1 (LSP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein 1 (LSP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC573Ra01 Recombinant Lymphocyte Specific Protein 1 (LSP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC573Ra01 Polyclonal Antibody to Lymphocyte Specific Protein 1 (LSP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein 1 (LSP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein 1 (LSP1) ELISA Kit Customized Service Offer
  1. "Human and mouse LSP1 genes code for highly conserved phosphoproteins."J. Immunol. 144:1104-1110(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen."Eur. J. Immunol. 20:2417-2423(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein."Blood 83:231-241(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization."Biochem. Biophys. Res. Commun. 358:170-175(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]