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Upstream Binding Transcription Factor (UBTF)

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NOR-90; UBF; Nucleolar Transcription Factor 1; Autoantigen NOR-90

Upstream Binding Transcription Factor (UBTF)
CCC C582
HGNC 12511
MGI 98512
PubMed 8825649
RGD 3927
UniProt P17480
Wiki UBTF
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes.
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Upstream Binding Transcription Factor (UBTF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Upstream Binding Transcription Factor (UBTF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Upstream Binding Transcription Factor (UBTF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Upstream Binding Transcription Factor (UBTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Upstream Binding Transcription Factor (UBTF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Upstream Binding Transcription Factor (UBTF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Upstream Binding Transcription Factor (UBTF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Upstream Binding Transcription Factor (UBTF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Upstream Binding Transcription Factor (UBTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Upstream Binding Transcription Factor (UBTF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Upstream Binding Transcription Factor (UBTF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Upstream Binding Transcription Factor (UBTF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Upstream Binding Transcription Factor (UBTF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Upstream Binding Transcription Factor (UBTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Upstream Binding Transcription Factor (UBTF) ELISA Kit Customized Service Offer
  1. "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins."Nature 344:830-836(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor."J. Exp. Med. 174:1239-1244(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Coactivator and promoter-selective properties of RNA polymerase I TAFs."Science 270:1506-1509(1995) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size."EMBO J. 29:897-909(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."Mol. Cell. Biol. 31:4676-4691(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis."J. Biol. Chem. 288:3174-3183(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the first HMG box domain in human upstream binding factor."Biochemistry 41:5415-5420(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor."Biochemistry 42:1930-1938(2003) [PubMed] [Europe PMC] [Abstract]