Beta-ureidopropionase (UPB1)
[Edit]UP-B1; BUP1; Beta-alanine synthase; Ureidopropionase Beta; N-carbamoyl-beta-alanine amidohydrolase
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The BUP1 open reading frame of 1,152 bp corresponds to a protein of 384 amino acids with a calculated molecular mass of 43 kD, surrounded by a 5-prime untranslated region of 61 nucleotides and a 3-prime untranslated region of 277 nucleotides. The protein shows 84% identity with the translation product of the rat beta-ureidopropionase cDNA.
Expression of the human cDNA in Escherichia coli and eukaryotic COS-7 cells revealed a very high beta-ureidopropionase enzymatic activity, thus confirming the identity of the cDNA. Human EST libraries from brain, liver, kidney, and heart contained partial beta-ureidopropionase cDNAs, suggesting expression in these tissues, as seen in the rat.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC587Hu01 | Recombinant Beta-ureidopropionase (UPB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC587Hu01 | Polyclonal Antibody to Beta-ureidopropionase (UPB1) | WB,IHC |
| Assay Kits | n/a | CLIA Kit for Beta-ureidopropionase (UPB1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Beta-ureidopropionase (UPB1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC587Mu01 | Recombinant Beta-ureidopropionase (UPB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC587Mu01 | Polyclonal Antibody to Beta-ureidopropionase (UPB1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Beta-ureidopropionase (UPB1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Beta-ureidopropionase (UPB1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Beta-ureidopropionase (UPB1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Beta-ureidopropionase (UPB1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Beta-ureidopropionase (UPB1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Beta-ureidopropionase (UPB1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Beta-ureidopropionase (UPB1) | ELISA Kit Customized Service Offer |
- "cDNA cloning, genomic structure and chromosomal localization of the human BUP-1 gene encoding beta-ureidopropionase."Biochim. Biophys. Acta 1447:251-257(1999) [PubMed] [Europe PMC] [Abstract]
- "Expression and properties of human liver beta-ureidopropionase."J. Nutr. Sci. Vitaminol. 47:132-138(2001) [PubMed] [Europe PMC] [Abstract]
- "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Beta-ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities."Hum. Mol. Genet. 13:2793-2801(2004) [PubMed] [Europe PMC] [Abstract]