≡

Ubiquitin Specific Peptidase 1 (USP1)

[Edit]

UBP; Ubiquitin Carboxyl-Terminal Hydrolase 1; Ubiquitin Specific Protease 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1

Ubiquitin Specific Peptidase 1 (USP1)
CCC C591
HGNC 12607
MGI 2385198
PubMed 19217432
RGD 1306461
UniProt O94782
Wiki USP1
Deubiquitinating enzymes (DUBs) are capable of producing a free ubiquitin moiety from ubiquitin-fused precursors and ubiquitylated proteins in cells. DUBs possess conserved catalytic regions known as the 'cys domain' and the 'his domain.'
Ubiquitin carboxyl-terminal hydrolase 1 is a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 1 (USP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 1 (USP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 1 (USP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC591Hu ELISA Kit for Ubiquitin Specific Peptidase 1 (USP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 1 (USP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 1 (USP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 1 (USP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 1 (USP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 1 (USP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC591Ra01 Recombinant Ubiquitin Specific Peptidase 1 (USP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC591Ra01 Polyclonal Antibody to Ubiquitin Specific Peptidase 1 (USP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 1 (USP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 1 (USP1) ELISA Kit Customized Service Offer
  1. "Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease."Genomics 54:155-158(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway."Mol. Cell 17:331-339(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of monoubiquitinated PCNA by DUB autocleavage."Nat. Cell Biol. 8:339-347(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway."Mol. Cell 28:786-797(2007) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]