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Ubiquitously Expressed Transcript (UXT)

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ART27; Androgen receptor trapped clone 27 protein; Ubiquitously expressed transcript protein

Ubiquitously Expressed Transcript (UXT)
CCC C592
HGNC 12641
MGI 1277988
PubMed 24021647
RGD 1359326
UniProt Q9UBK9
Wiki UXT
Protein UXT is a novel protein which is highly conserved in mouse. It interacts with the N-terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is also likely to be involved in tumorigenesis as it is abundantly expressed in tumor tissues. This gene is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding different isoforms.
Based on a consensus sequence from 14 different ESTs with significant sequence similarity to UXT, they determined that UXT encodes a 157-amino acid protein with 3 potential phosphorylation sites. a protein that shares 90% identity with human UXT, with all 3 potential phosphorylation sites conserved, indicating that these sites are of functional importance.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC592Hu01 Recombinant Ubiquitously Expressed Transcript (UXT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC592Hu01 Polyclonal Antibody to Ubiquitously Expressed Transcript (UXT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitously Expressed Transcript (UXT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitously Expressed Transcript (UXT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC592Mu01 Recombinant Ubiquitously Expressed Transcript (UXT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC592Mu01 Polyclonal Antibody to Ubiquitously Expressed Transcript (UXT) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitously Expressed Transcript (UXT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitously Expressed Transcript (UXT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitously Expressed Transcript (UXT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitously Expressed Transcript (UXT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitously Expressed Transcript (UXT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitously Expressed Transcript (UXT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitously Expressed Transcript (UXT) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."Genomics 56:340-343(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus."Mol. Biol. Cell 13:670-682(2002) [PubMed] [Europe PMC] [Abstract]
  3. "UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation."FEBS J. 274:3960-3971(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity."Genomics 79:124-136(2002) [PubMed] [Europe PMC] [Abstract]
  9. "UXT is a novel centrosomal protein essential for cell viability."Mol. Biol. Cell 16:5857-5865(2005) [PubMed] [Europe PMC] [Abstract]
  10. "UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation."In Vitro Cell. Dev. Biol. Anim. 43:139-146(2007) [PubMed] [Europe PMC] [Abstract]
  11. "UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome."J. Cell Biol. 178:231-244(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP."Mol. Cell. Biol. 31:3639-3652(2011) [PubMed] [Europe PMC] [Abstract]