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X-Box Binding Protein 1 (XBP1)

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TREB5; XBP2; Tax-responsive element-binding protein 5

X-Box Binding Protein 1 (XBP1)
CCC C605
HGNC 12801
MGI 98970
PubMed 9343412
RGD 1303073
UniProt P17861
Wiki XBP1
X-box binding protein 1is a a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC605Hu01 Recombinant X-Box Binding Protein 1 (XBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC605Hu01 Polyclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
MAC605Hu22 Monoclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
Assay Kits SEC605Hu ELISA Kit for X-Box Binding Protein 1 (XBP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC605Hu CLIA Kit for X-Box Binding Protein 1 (XBP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC605Mu01 Recombinant X-Box Binding Protein 1 (XBP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC605Mu02 Recombinant X-Box Binding Protein 1 (XBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC605Mu01 Polyclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
PAC605Mu02 Polyclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
Assay Kits SEC605Mu ELISA Kit for X-Box Binding Protein 1 (XBP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC605Mu CLIA Kit for X-Box Binding Protein 1 (XBP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC605Ra01 Recombinant X-Box Binding Protein 1 (XBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC605Ra01 Polyclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
MAC605Ra21 Monoclonal Antibody to X-Box Binding Protein 1 (XBP1) WB; IHC; ICC; IP.
Assay Kits SEC605Ra ELISA Kit for X-Box Binding Protein 1 (XBP1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  3. "The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes."J. Biol. Chem. 268:17074-17082(1993) [PubMed] [Europe PMC] [Abstract]
  4. "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor."Cell 107:881-891(2001) [PubMed] [Europe PMC] [Abstract]
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  8. "Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos."Proc. Natl. Acad. Sci. U.S.A. 88:4309-4312(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1."J. Exp. Med. 183:393-401(1996) [PubMed] [Europe PMC] [Abstract]
  10. "The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core."Nucleic Acids Res. 24:1855-1864(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells."Int. J. Oncol. 15:173-178(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Plasma cell differentiation requires the transcription factor XBP-1."Nature 412:300-307(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder."Nat. Genet. 35:171-175(2003) [PubMed] [Europe PMC] [Abstract]
  14. "XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum."J. Cell Biol. 167:35-41(2004) [PubMed] [Europe PMC] [Abstract]
  15. "XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells."Cell Struct. Funct. 31:117-125(2006) [PubMed] [Europe PMC] [Abstract]
  16. "pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response."J. Cell Biol. 172:565-575(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1."Dev. Cell 13:365-376(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response."J. Cell Sci. 122:2877-2886(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA."Mol. Cell 34:191-200(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow."Proc. Natl. Acad. Sci. U.S.A. 106:8326-8331(2009) [PubMed] [Europe PMC] [Abstract]
  21. "A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response."Nat. Med. 16:438-445(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation."Biochem. J. 433:245-252(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA."Science 331:586-589(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis."Circulation 127:1712-1722(2013) [PubMed] [Europe PMC] [Abstract]
  25. "XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation."J. Biol. Chem. 288:859-872(2013) [PubMed] [Europe PMC] [Abstract]
  26. "XBP1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cells."Cell. Signal. 27:82-89(2015) [PubMed] [Europe PMC] [Abstract]
  27. "Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u."EMBO J. 33:2492-2506(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3."J. Biol. Chem. 289:30625-30634(2014) [PubMed] [Europe PMC] [Abstract]
  29. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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