Xanthine Dehydrogenase (XDH)
[Edit]XO; XOR; XOD; Xanthine Oxidase; NAD+-Xanthine Dehydrogenase; Xanthine-NAD+ Oxidoreductase; Xanthine/NAD+ Oxidoreductase; Xanthine Oxidoreductase
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Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
The three substrates of this enzyme are xanthine, NAD+, and H2O, whereas its three products are urate, NADH, and H+.This enzyme belongs to the family of oxidoreductases, to be specific, those acting on CH or CH2 group with NAD+ or NADP+ as acceptor.Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC608Hu01 | Recombinant Xanthine Dehydrogenase (XDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC608Hu01 | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. |
| MAC608Hu22 | Monoclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC608Hu | ELISA Kit for Xanthine Dehydrogenase (XDH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC608Hu | CLIA Kit for Xanthine Dehydrogenase (XDH) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC608Mu01 | Recombinant Xanthine Dehydrogenase (XDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC608Mu02 | Recombinant Xanthine Dehydrogenase (XDH) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC608Mu01 | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. |
| PAC608Mu02 | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC608Mu | ELISA Kit for Xanthine Dehydrogenase (XDH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC608Mu | CLIA Kit for Xanthine Dehydrogenase (XDH) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC608Ra01 | Recombinant Xanthine Dehydrogenase (XDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC608Ra01 | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. |
| MAC608Ra21 | Monoclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC608Ra | ELISA Kit for Xanthine Dehydrogenase (XDH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Xanthine Dehydrogenase (XDH) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Xanthine Dehydrogenase (XDH) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Xanthine Dehydrogenase (XDH) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Xanthine Dehydrogenase (XDH) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC608Bo01 | Recombinant Xanthine Dehydrogenase (XDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC608Bo01 | Polyclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. |
| MAC608Bo21 | Monoclonal Antibody to Xanthine Dehydrogenase (XDH) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC608Bo | ELISA Kit for Xanthine Dehydrogenase (XDH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC608Bo | CLIA Kit for Xanthine Dehydrogenase (XDH) | Chemiluminescent immunoassay for Antigen Detection. |
- "Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene."Gene 133:279-284(1993) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning, tissue expression of human xanthine dehydrogenase."Biochem. Biophys. Res. Commun. 199:998-1004(1994) [PubMed] [Europe PMC] [Abstract]
- ErratumBiochem. Biophys. Res. Commun. 215:429-429(1995) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression in vitro of human xanthine dehydrogenase/oxidase."Biochem. J. 315:235-239(1996) [PubMed] [Europe PMC] [Abstract]
- "Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria."J. Clin. Invest. 99:2391-2397(1997) [PubMed] [Europe PMC] [Abstract]
- "XDH gene mutation is the underlying cause of classical xanthinuria: a second report."Kidney Int. 57:2215-2220(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate."J. Biochem. 141:513-524(2007) [PubMed] [Europe PMC] [Abstract]
- "Human milk xanthine dehydrogenase is incompletely converted to the oxidase form in the absence of proteolysis. A structural explanation."Submitted (FEB-2009) to the PDB data bank
- "Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria."Hum. Genet. 108:279-283(2001) [PubMed] [Europe PMC] [Abstract]
- "Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria."Nephrol. Dial. Transplant. 18:2278-2283(2003) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]