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Major Intrinsic Protein (MIP)

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AQP0; LIM1; AQP-0; MIP26; MP26; Major Intrinsic Protein Of Lens Fiber; Aquaporin 0; Lens fiber major intrinsic protein

Major Intrinsic Protein (MIP)
CCC C621
HGNC 7103
MGI 96990
PubMed 11919287
RGD 3090
UniProt P30301
Wiki MIP
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Intrinsic Protein (MIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Intrinsic Protein (MIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Intrinsic Protein (MIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Intrinsic Protein (MIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Intrinsic Protein (MIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Intrinsic Protein (MIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Intrinsic Protein (MIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Intrinsic Protein (MIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Intrinsic Protein (MIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Intrinsic Protein (MIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Intrinsic Protein (MIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Intrinsic Protein (MIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Intrinsic Protein (MIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Intrinsic Protein (MIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Intrinsic Protein (MIP) ELISA Kit Customized Service Offer
  1. "Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens."Genomics 11:981-990(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of human lens major intrinsic protein structure."Invest. Ophthalmol. Vis. Sci. 41:175-182(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q."Nat. Genet. 25:15-17(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Novel single-base deletional mutation in major intrinsic protein (MIP) in autosomal dominant cataract."Am. J. Ophthalmol. 141:761-763(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Functional impairment of lens aquaporin in two families with dominantly inherited cataracts."Hum. Mol. Genet. 9:2329-2334(2000) [PubMed] [Europe PMC] [Abstract]
  8. "A novel mutation in major intrinsic protein of the lens gene (MIP) underlies autosomal dominant cataract in a Chinese family."Mol. Vis. 13:1651-1656(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A substitution of arginine to lysine at the COOH-terminus of MIP caused a different binocular phenotype in a congenital cataract family."Mol. Vis. 13:1822-1827(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family."Mol. Vis. 16:534-539(2010) [PubMed] [Europe PMC] [Abstract]
  11. "A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family."Mol. Vis. 17:70-77(2011) [PubMed] [Europe PMC] [Abstract]