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Multimerin 1 (MMRN1)

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ECM; EMILIN4; GPIa; MMRN; Glycoprotein Ia; Elastin microfibril interface located protein 4; Endothelial cell multimerin; Platelet glycoprotein Ia; 155 kDa platelet multimerin

Multimerin 1 (MMRN1)
CCC C622
HGNC 7178
MGI 1918195
PubMed 19132231
RGD 1587248
UniProt Q13201
Wiki MMRN1
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder were found to have a deficiency of platelet multimerin.Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC622Hu01 Recombinant Multimerin 1 (MMRN1) Positive Control; Immunogen; SDS-PAGE; WB.
APC622Hu01 Active Multimerin 1 (MMRN1) Cell culture; Activity Assays.
Antibodies PAC622Hu01 Polyclonal Antibody to Multimerin 1 (MMRN1) WB; IHC; ICC; IP.
MAC622Hu22 Monoclonal Antibody to Multimerin 1 (MMRN1) WB; IHC; ICC; IP.
LAC622Hu81 FITC-Linked Polyclonal Antibody to Multimerin 1 (MMRN1) WB; IHC; ICC; IF.
Assay Kits SEC622Hu ELISA Kit for Multimerin 1 (MMRN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Multimerin 1 (MMRN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Multimerin 1 (MMRN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Multimerin 1 (MMRN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Multimerin 1 (MMRN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Multimerin 1 (MMRN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC622Ra01 Recombinant Multimerin 1 (MMRN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC622Ra01 Polyclonal Antibody to Multimerin 1 (MMRN1) WB; IHC; ICC; IP.
MAC622Ra21 Monoclonal Antibody to Multimerin 1 (MMRN1) WB; IHC; ICC; IP.
Assay Kits SEC622Ra ELISA Kit for Multimerin 1 (MMRN1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The cDNA sequence of human endothelial cell multimerin. A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X."J. Biol. Chem. 270:18246-18251(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Platelet glycoprotein Ia* is the processed form of multimerin --isolation and determination of N-terminal sequences of stored and released forms."Thromb. Haemost. 80:645-648(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line."J. Clin. Invest. 91:2630-2639(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Platelet multimerin and its proteolytic processing."Thromb. Haemost. 82:1779-1780(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3."Thromb. Haemost. 94:1004-1011(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation."Thromb. Haemost. 100:1058-1067(2008) [PubMed] [Europe PMC] [Abstract]
  13. "An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect."Blood 87:4967-4978(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]