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Molybdenum Cofactor Synthesis 1 (MOCS1)

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MIG11; MOCOD; MOCS1A; MOCS1B; Molybdenum Cofactor Biosynthesis Protein 1; Cell migration-inducing gene 11 protein; Cyclic pyranopterin monophosphate synthase accessory

Molybdenum Cofactor Synthesis 1 (MOCS1)
CCC C623
HGNC 7190
MGI 1928904
PubMed 12754701
RGD 1308471
UniProt O14940
Wiki MOCS1
Molybdenum cofactor biosynthesis protein 1 is a protein encoded by the MOCS1 gene.Both copies of this gene are defective in patients with molybdenum cofactor deficiency, type A.Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. Molybdenum cofactor biosynthesis protein 1 is involved in molybdenum cofactor biosynthesis. (This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA.) Two of the splice variants found for this gene express proteins (MOCS1A-MOCS1B) that result from a fusion between the two open reading frames.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC623Hu01 Recombinant Molybdenum Cofactor Synthesis 1 (MOCS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC623Hu01 Polyclonal Antibody to Molybdenum Cofactor Synthesis 1 (MOCS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC623Mu01 Recombinant Molybdenum Cofactor Synthesis 1 (MOCS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC623Mu01 Polyclonal Antibody to Molybdenum Cofactor Synthesis 1 (MOCS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Synthesis 1 (MOCS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 1 (MOCS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 1 (MOCS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 1 (MOCS1) ELISA Kit Customized Service Offer
  1. "Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency."Nat. Genet. 20:51-53(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames."RNA 6:928-936(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis."J. Biol. Chem. 277:18303-18312(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The bicistronic MOCS1 gene has alternative start codons on two mutually exclusive exons."Mol. Genet. Metab. 76:340-343(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis."J. Biol. Chem. 279:34721-34732(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A."Hum. Genet. 103:639-644(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH."Hum. Mutat. 21:569-576(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase."Hum. Genet. 117:565-570(2005) [PubMed] [Europe PMC] [Abstract]