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Microseminoprotein Beta (MSMb)

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MSM-B; IGBF; MSP; MSPB; PN44; PRPS; PSP; PSP57; PSP94; Immunoglobulin-binding factor; Prostate secreted seminal plasma protein; plasma beta-inhibin

Microseminoprotein Beta (MSMb)
CCC C628
HGNC 7372
MGI 97166
PubMed 22661295
RGD 3113
UniProt P08118
Wiki MSMB
Beta-microseminoprotein is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC628Hu01 Recombinant Microseminoprotein Beta (MSMb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC628Hu01 Polyclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC
MAC628Hu22 Monoclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC; ICC; IP.
LAC628Hu71 Biotin-Linked Polyclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC; ICC.
LAC628Hu81 FITC-Linked Polyclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC; ICC; IF.
Assay Kits SEC628Hu ELISA Kit for Microseminoprotein Beta (MSMb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC628Mu01 Recombinant Microseminoprotein Beta (MSMb) Positive Control; Immunogen; SDS-PAGE; WB.
RPC628Mu02 Recombinant Microseminoprotein Beta (MSMb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC628Mu01 Polyclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC; ICC; IP.
PAC628Mu02 Polyclonal Antibody to Microseminoprotein Beta (MSMb) WB; IHC; ICC; IP.
Assay Kits SEC628Mu ELISA Kit for Microseminoprotein Beta (MSMb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microseminoprotein Beta (MSMb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microseminoprotein Beta (MSMb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microseminoprotein Beta (MSMb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microseminoprotein Beta (MSMb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microseminoprotein Beta (MSMb) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate."DNA 6:23-29(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a small prostate protein, known as beta-microseminoprotein, PSP94 or beta-inhibin, and demonstration of transcripts in non-genital tissues."Biochem. Biophys. Res. Commun. 164:1310-1315(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and nucleotide sequence analysis of the human beta-microseminoprotein gene."Biochem. Biophys. Res. Commun. 167:1184-1190(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human."Biochim. Biophys. Acta 1089:247-249(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Decreased expression of prostatic secretory protein PSP94 in prostate cancer."Cancer Lett. 74:91-99(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue."Oncogene 11:1041-1047(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "New world, but not old world, monkeys carry several genes encoding beta-microseminoprotein."Eur. J. Biochem. 264:407-414(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The amino acid sequence of human beta-microseminoprotein."Biochim. Biophys. Acta 829:288-294(1985) [PubMed] [Europe PMC] [Abstract]
  11. "Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site."FEBS Lett. 175:349-355(1984) [PubMed] [Europe PMC] [Abstract]
  12. "Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma."Biochem. Biophys. Res. Commun. 180:356-359(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Human seminal plasma beta-microseminoprotein: its purification, characterization, and immunohistochemical localization."Int. J. Biochem. Cell Biol. 27:603-611(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids."Biochem. J. 385:105-114(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Multiple loci identified in a genome-wide association study of prostate cancer." Nat. Genet. 40:310-315(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression."Hum. Mutat. 34:149-156(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structures of human and porcine beta-microseminoprotein."J. Mol. Biol. 362:502-515(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer."J. Mol. Biol. 397:947-956(2010) [PubMed] [Europe PMC] [Abstract]