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Metaxin 1 (MTX1)

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MTXN; Mitochondrial outer membrane import complex protein 1

Metaxin 1 (MTX1)
CCC C636
HGNC 7504
MGI 103025
PubMed 15024629
UniProt Q13505
Wiki MTX1
Metaxin 1, is a protein located on the outer membrane of mitochondria, is a component of the mitochondrial protein translocation apparatus.that spans the 6-kb interval separating the glucocerebrosidase gene (GBA) from the thrombospondin III geneon chromosome 3. Metaxin (so named from a Greek word for 'in between') and GBA are transcribed convergently; their major polyadenylation sites are only 431 bp apart. On the other hand, metaxin and the Tsp3 gene are transcribed divergently and share a common promoter sequence. The cDNA from metaxin encodes a 317-amino acid protein which lacks both a signal sequence and a consensus sequence for N-linked glycosylation. Metaxin protein is expressed ubiquitously in tissues of the young adult mouse. No close homologs were found in the DNA or protein databases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC636Hu01 Recombinant Metaxin 1 (MTX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC636Hu01 Polyclonal Antibody to Metaxin 1 (MTX1) WB,IHC
Assay Kits n/a CLIA Kit for Metaxin 1 (MTX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Metaxin 1 (MTX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC636Mu01 Recombinant Metaxin 1 (MTX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC636Mu01 Polyclonal Antibody to Metaxin 1 (MTX1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Metaxin 1 (MTX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Metaxin 1 (MTX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC636Ra01 Recombinant Metaxin 1 (MTX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC636Ra01 Polyclonal Antibody to Metaxin 1 (MTX1) WB,IHC
Assay Kits n/a CLIA Kit for Metaxin 1 (MTX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Metaxin 1 (MTX1) ELISA Kit Customized Service Offer
  1. "Structure and organization of the human metaxin gene (MTX) and pseudogene."Genomics 33:177-184(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease."Genome Res. 7:1020-1026(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane."J. Cell. Biochem. 74:11-22(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
  9. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]