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Megakaryocyte Associated Tyrosine Kinase (MATK)

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CHK; CTK; HHYLTK; HYL; HYLTK; Lsk; Csk-Homologous Kinase; Hematopoietic Consensus Tyrosine-Lacking Kinase; Tyrosylprotein Kinase; Hydroxyaryl Protein Kinase

Megakaryocyte Associated Tyrosine Kinase (MATK)
CCC C638
HGNC 6906
MGI 99259
PubMed 21653353
RGD 69058
UniProt P42679
Wiki MATK
MATKis an enzyme has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site.
This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Megakaryocyte Associated Tyrosine Kinase (MATK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Megakaryocyte Associated Tyrosine Kinase (MATK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Megakaryocyte Associated Tyrosine Kinase (MATK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC638Mu01 Recombinant Megakaryocyte Associated Tyrosine Kinase (MATK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Megakaryocyte Associated Tyrosine Kinase (MATK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Megakaryocyte Associated Tyrosine Kinase (MATK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC638Ra01 Recombinant Megakaryocyte Associated Tyrosine Kinase (MATK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC638Ra01 Polyclonal Antibody to Megakaryocyte Associated Tyrosine Kinase (MATK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Megakaryocyte Associated Tyrosine Kinase (MATK) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)."Oncogene 9:1155-1161(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a novel tyrosine kinase from megakaryocytes."J. Biol. Chem. 269:1068-1074(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product."J. Biol. Chem. 270:1833-1842(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of mouse non-receptor tyrosine kinase gene, HYL."Oncogene 9:3371-3374(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets."EMBO J. 16:2342-2351(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes."J. Biol. Chem. 272:5915-5920(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."Biochem. Biophys. Res. Commun. 337:1-13(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structures of the SH3 domain of human megakaryocyte-associated tyrosine-protein kinase."Submitted (NOV-2005) to the PDB data bank
  18. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]