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Monoamine Oxidase B (MAOB)

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MAO-B; Amine oxidase [flavin-containing] B

Monoamine Oxidase B (MAOB)
CCC C643
HGNC 6834
MGI 96916
PubMed 9326944
RGD 3041
UniProt P27338
Wiki MAOB
Monoamine oxidase B, is a protein belongs to the flavin monoamine oxidase family. It is an enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.Edmondson et al. described structural features of the human enzyme: it has a hydrophobic bipartite elongated cavity that (for the "open" conformation) occupies a combined volume close to 700 Å3. hMAO-A has a single cavity that exhibits a rounder shape and is larger in volume than the "substrate cavity" of hMAO-B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC643Hu01 Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Monoamine Oxidase B (MAOB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Monoamine Oxidase B (MAOB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Monoamine Oxidase B (MAOB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Monoamine Oxidase B (MAOB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC643Mu01 Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC643Mu01 Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
Assay Kits SEC643Mu ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC643Ra01 Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Monoamine Oxidase B (MAOB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Monoamine Oxidase B (MAOB) Polyclonal Antibody Customized Service Offer
Assay Kits SEC643Ra ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988) [PubMed] [Europe PMC] [Abstract]
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  9. "Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines."Mol. Pharmacol. 43:888-893(1993) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders."Nat. Struct. Biol. 9:22-26(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures."Proc. Natl. Acad. Sci. U.S.A. 100:9750-9755(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class."J. Med. Chem. 47:1767-1774(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors."J. Biol. Chem. 280:15761-15766(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis."J. Med. Chem. 48:8148-8154(2005) [PubMed] [Europe PMC] [Abstract]