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Nuclear Transcription Factor Y Alpha (NFYa)

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NFY-A; CBF-A; CBF-B; HAP2; NF-YA; CAAT box DNA-binding protein subunit A

Nuclear Transcription Factor Y Alpha (NFYa)
CCC C656
HGNC 7804
MGI 97316
PubMed 22530004
RGD 70976
UniProt P23511
Wiki NFYA
Nuclear transcription factor Y subunit alpha is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transcription Factor Y Alpha (NFYa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transcription Factor Y Alpha (NFYa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transcription Factor Y Alpha (NFYa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transcription Factor Y Alpha (NFYa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transcription Factor Y Alpha (NFYa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transcription Factor Y Alpha (NFYa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transcription Factor Y Alpha (NFYa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transcription Factor Y Alpha (NFYa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transcription Factor Y Alpha (NFYa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transcription Factor Y Alpha (NFYa) ELISA Kit Customized Service Offer
  1. "Evolutionary variation of the CCAAT-binding transcription factor NF-Y."Nucleic Acids Res. 20:1087-1091(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast."Proc. Natl. Acad. Sci. U.S.A. 88:1968-1972(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y."Biochem. Biophys. Res. Commun. 261:614-621(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of proteins that interact with NF-YA."FEBS Lett. 460:41-45(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor."Biochem. J. 373:747-757(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y."Biochem. Biophys. Res. Commun. 382:593-597(2009) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination."Cell 152:132-143(2013) [PubMed] [Europe PMC] [Abstract]