≡

Nucleolar Protein 1 (NOL1)

[Edit]

NOP2; p120; NOP120; NSUN1; Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar p120

Nucleolar Protein 1 (NOL1)
CCC C661
HGNC 7867
MGI 107891
PubMed 18405070
RGD 1304616
UniProt P46087
Wiki NOL1
Putative ribosomal RNA methyltransferase NOP2 is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.
Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.
The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 1 (NOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 1 (NOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 1 (NOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 1 (NOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 1 (NOL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 1 (NOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 1 (NOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 1 (NOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 1 (NOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 1 (NOL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 1 (NOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 1 (NOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 1 (NOL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 1 (NOL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 1 (NOL1) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120."Cancer Commun. 1:243-251(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the human proliferating cell nucleolar protein p120."Cancer Commun. 2:63-71(1990) [PubMed] [Europe PMC] [Abstract]
  3. "A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation."Cancer Res. 52:5681-5686(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120."Eur. J. Biochem. 253:734-742(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21."Genes Cells 18:780-797(2013) [PubMed] [Europe PMC] [Abstract]