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Neuro Oncological Ventral Antigen 1 (NOVA1)

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Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1; RNA-binding protein Nova-1

Neuro Oncological Ventral Antigen 1 (NOVA1)
CCC C662
HGNC 7886
MGI 104297
PubMed 10719891
UniProt P51513
Wiki NOVA1
RNA-binding protein Nova-1 is a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA), a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer, fallopian cancer, and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC662Hu01 Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC662Hu01 Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) WB; IHC
Assay Kits n/a CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) ELISA Kit Customized Service Offer
  1. "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system."Neuron 11:657-672(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence of the human genome." Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains."Structure 7:191-203(1999) [PubMed] [Europe PMC] [Abstract]