Neuronal Pentraxin Receptor (NPTXR)

Neuronal pentraxin receptor is a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.

The deduced 494-amino acid protein is translated from an initiating CTG codon. Npr contains 3 potential N-glycosylation sites and an N-terminal transmembrane stretch. It shares significant homology with Np1 (NPTX1) and Np2 (NPTX2), particularly in its C-terminal half, which includes the calcium binding residues and pentraxin signature sequence.