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Nuclear Respiratory Factor 1 (NRF1)

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ALPHA-PAL; EWG; Alpha Palindromic-Binding Protein

Nuclear Respiratory Factor 1 (NRF1)
CCC C669
HGNC 7996
MGI 1332235
PubMed 20805060
RGD 1304603
UniProt Q16656
Wiki NRF1
Nuclear respiratory factor 1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized.Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Respiratory Factor 1 (NRF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Respiratory Factor 1 (NRF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Respiratory Factor 1 (NRF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Respiratory Factor 1 (NRF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Respiratory Factor 1 (NRF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC669Mu01 Recombinant Nuclear Respiratory Factor 1 (NRF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC669Mu01 Polyclonal Antibody to Nuclear Respiratory Factor 1 (NRF1) WB; IHC; ICC; IP.
Assay Kits SEC669Mu ELISA Kit for Nuclear Respiratory Factor 1 (NRF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC669Ra01 Recombinant Nuclear Respiratory Factor 1 (NRF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC669Ra01 Polyclonal Antibody to Nuclear Respiratory Factor 1 (NRF1) WB; IHC; ICC; IP.
MAC669Ra21 Monoclonal Antibody to Nuclear Respiratory Factor 1 (NRF1) WB; IHC; ICC; IP.
Assay Kits SEC669Ra ELISA Kit for Nuclear Respiratory Factor 1 (NRF1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators."Genes Dev. 7:2431-2445(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development."J. Biol. Chem. 269:18921-18930(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1."J. Biol. Chem. 270:18019-18025(1995) [PubMed] [Europe PMC] [Abstract]
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  8. "The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines."Hum. Mol. Genet. 4:1591-1596(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding."J. Biol. Chem. 272:18732-18739(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract]
  11. "PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]