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Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver.
Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC692Hu01 | Recombinant Opticin (OPTC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC692Hu01 | Polyclonal Antibody to Opticin (OPTC) | WB; IHC; ICC; IP. |
| MAC692Hu22 | Monoclonal Antibody to Opticin (OPTC) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC692Hu | ELISA Kit for Opticin (OPTC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Opticin (OPTC) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Opticin (OPTC) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Opticin (OPTC) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Opticin (OPTC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Opticin (OPTC) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Opticin (OPTC) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Opticin (OPTC) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Opticin (OPTC) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Opticin (OPTC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Opticin (OPTC) | ELISA Kit Customized Service Offer |
- "Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix."J. Biol. Chem. 275:2123-2129(2000) [PubMed] [Europe PMC] [Abstract]
- "Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye."Mol. Vis. 6:72-78(2000) [PubMed] [Europe PMC] [Abstract]
- "Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection."Invest. Ophthalmol. Vis. Sci. 41:2059-2066(2000) [PubMed] [Europe PMC] [Abstract]
- "Protein localization in the human eye and genetic screen of opticin."Hum. Mol. Genet. 11:1333-1342(2002) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]