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Osteopetrosis Associated Transmembrane Protein 1 (OSTM1)

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GL; GIPN; Chloride channel 7 beta subunit

Osteopetrosis Associated Transmembrane Protein 1 (OSTM1)
CCC C696
HGNC 21652
MGI 2655574
PubMed 16813530
RGD 1564976
UniProt Q86WC4
Wiki OSTM1
Osteopetrosis-associated transmembrane protein 1 is a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity.
This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.The OSTM1 gene is regulated by the Microphthalmia-associated transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC696Hu01 Recombinant Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC696Hu01 Polyclonal Antibody to Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC696Mu01 Recombinant Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC696Mu01 Polyclonal Antibody to Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC696Ra01 Recombinant Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC696Ra01 Polyclonal Antibody to Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) ELISA Kit Customized Service Offer
  1. "Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human."Nat. Med. 9:399-406(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement."J. Bone Miner. Res. 21:1098-1105(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity."EMBO J. 30:2140-2152(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]