≡

Otoraplin (OTOR)

[Edit]

FDP; MIAL; MIAL1; Fibrocyte-derived protein; Melanoma inhibitory activity-like protein

Otoraplin (OTOR)
CCC C699
HGNC 8517
MGI 1888678
PubMed 10873378
RGD 1305253
UniProt Q9NRC9
Wiki OTOR
Otoraplin is a protein secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. This gene is a member of the melanoma-inhibiting activity gene family. In addition, alternate polyA sites exist for this gene.Human OTOR encodes a 128-amino acid protein with a predicted secretion signal peptide. The protein shares high sequence identity with the mouse (90%), chicken (80%), and bullfrog (60%) orthologs and with the related human CDRAP/MIA protein (43%). OTOR is translated as an approximately 15-kD polypeptide that is assembled into a covalently linked homodimer, modified by sulfation, and secreted from the cells via the Golgi apparatus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Otoraplin (OTOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Otoraplin (OTOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Otoraplin (OTOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Otoraplin (OTOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Otoraplin (OTOR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC699Mu01 Recombinant Otoraplin (OTOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC699Mu01 Polyclonal Antibody to Otoraplin (OTOR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Otoraplin (OTOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Otoraplin (OTOR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Otoraplin (OTOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Otoraplin (OTOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Otoraplin (OTOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Otoraplin (OTOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Otoraplin (OTOR) ELISA Kit Customized Service Offer
  1. "A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping."Genomics 66:242-248(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme."J. Biol. Chem. 275:40036-40041(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation."Genomics 71:40-52(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]