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Optineurin (OPTN)

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NRP; FIP2; GLC1E; HIP7; HYPL; TFIIIA-INTP; Glaucoma 1,Open Angle,E(Adult-Onset); Huntingtin-interacting protein 7; Optic neuropathy-inducing protein; E3-14.7K-interacting protein

Optineurin (OPTN)
CCC C702
HGNC 17142
MGI 1918898
PubMed 20428114
RGD 628886
UniProt Q96CV9
Wiki Optineurin
Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction.
Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Optineurin (OPTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Optineurin (OPTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Optineurin (OPTN) Polyclonal Antibody Customized Service Offer
Assay Kits SEC702Hu ELISA Kit for Optineurin (OPTN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC702Mu01 Recombinant Optineurin (OPTN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC702Mu02 Recombinant Optineurin (OPTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC702Mu01 Polyclonal Antibody to Optineurin (OPTN) WB; IHC; ICC; IP.
PAC702Mu02 Polyclonal Antibody to Optineurin (OPTN) WB; IHC; ICC; IP.
Assay Kits SEC702Mu ELISA Kit for Optineurin (OPTN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Optineurin (OPTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Optineurin (OPTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Optineurin (OPTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Optineurin (OPTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Optineurin (OPTN) ELISA Kit Customized Service Offer
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  2. "Adult-onset primary open-angle glaucoma caused by mutations in optineurin."Science 295:1077-1079(2002) [PubMed] [Europe PMC] [Abstract]
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  10. "Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure."Biochem. Biophys. Res. Commun. 298:67-74(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation."Ophthalmic Res. 35:93-96(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis."J. Cell Biol. 169:285-295(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant."BMC Cell Biol. 11:4-4(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection."PLoS Pathog. 6:E1000778-E1000778(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17."J. Cell Sci. 125:5026-5039(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "The LIR motif - crucial for selective autophagy."J. Cell Sci. 126:3237-3247(2013) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for phosphorylation-triggered autophagic clearance of Salmonella."Biochem. J. 454:459-466(2013) [PubMed] [Europe PMC] [Abstract]
  24. "The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma."J. Med. Genet. 40:842-844(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Different optineurin mutation pattern in primary open-angle glaucoma."Invest. Ophthalmol. Vis. Sci. 44:3880-3884(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma."Am. J. Ophthalmol. 136:904-910(2003) [PubMed] [Europe PMC] [Abstract]
  27. "M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells."Autophagy 9:510-527(2013) [PubMed] [Europe PMC] [Abstract]
  28. "E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy."PLoS ONE 9:E95758-E95758(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma."Hum. Mol. Genet. 22:3559-3567(2013) [PubMed] [Europe PMC] [Abstract]
  30. "Analysis of optineurin (OPTN) gene mutations in subjects with and without glaucoma: the blue mountains eye study."Clin. Exp. Ophthalmol. 32:518-522(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Defining the pathogenicity of optineurin in juvenile open-angle glaucoma."Invest. Ophthalmol. Vis. Sci. 45:3122-3130(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma." Invest. Ophthalmol. Vis. Sci. 45:4359-4367(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population."J. Glaucoma 13:299-303(2004) [PubMed] [Europe PMC] [Abstract]
  34. "Clinical relevance of optineurin sequence alterations in Japanese glaucoma patients."Ophthalmic Genet. 25:91-99(2004) [PubMed] [Europe PMC] [Abstract]
  35. "A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants."Invest. Ophthalmol. Vis. Sci. 48:1607-1614(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Mutations of optineurin in amyotrophic lateral sclerosis." Nature 465:223-226(2010) [PubMed] [Europe PMC] [Abstract]
  37. "Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth."Science 333:228-233(2011) [PubMed] [Europe PMC] [Abstract]