≡

Oxoguanine Glycosylase 1 (OGG1)

[Edit]

HMMH; HOGG1; MUTM; OGH1; 8-Oxoguanine DNA Glycosylase; DNA-(apurinic or apyrimidinic site) lyase; N-glycosylase/DNA lyase

Oxoguanine Glycosylase 1 (OGG1)
CCC C704
HGNC 8125
MGI 1097693
PubMed 16614128
RGD 621168
UniProt O15527
Wiki OGG1
OGG1 is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targeting signal, essential for mitochondrial localization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC704Hu01 Recombinant Oxoguanine Glycosylase 1 (OGG1) Positive Control; Immunogen; SDS-PAGE; WB.
APC704Hu01 Active Oxoguanine Glycosylase 1 (OGG1) Cell culture; Activity Assays.
Antibodies PAC704Hu01 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) WB; IHC; ICC; IP.
MAC704Hu22 Monoclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) WB; IHC; ICC; IP.
Assay Kits SEC704Hu ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC704Mu01 Recombinant Oxoguanine Glycosylase 1 (OGG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC704Mu02 Recombinant Oxoguanine Glycosylase 1 (OGG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC704Mu01 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) WB; IHC; ICC; IP.
PAC704Mu02 Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) WB; IHC; ICC; IP.
Assay Kits SEC704Mu ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxoguanine Glycosylase 1 (OGG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxoguanine Glycosylase 1 (OGG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxoguanine Glycosylase 1 (OGG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxoguanine Glycosylase 1 (OGG1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue."Cancer Res. 57:2151-2156(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase."Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase."Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae."Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997) [PubMed] [Europe PMC] [Abstract]
  5. "A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer."Curr. Biol. 7:397-407(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage."Oncogene 14:2857-2861(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers."J. Exp. Med. 186:1547-1556(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites."EMBO J. 16:6314-6322(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Structure and chromosome location of human OGG1."Cytogenet. Cell Genet. 85:232-236(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Expression and differential intracellular localization of two major forms of human 8-Oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs."Mol. Biol. Cell 10:1637-1652(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  14. "The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis."Arch. Biochem. Biophys. 377:1-8(2000) [PubMed] [Europe PMC] [Abstract]
  15. "UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles."J. Cell Sci. 120:23-32(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA."Nature 403:859-866(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Reciprocal 'flipping'; underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase."J. Mol. Biol. 317:171-177(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase."Biochemistry 42:1564-1572(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Product-assisted catalysis in base-excision DNA repair."Nat. Struct. Biol. 10:204-211(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Structures of end products resulting from lesion processing by a DNA glycosylase/lyase."Chem. Biol. 11:1643-1649(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations."J. Biol. Chem. 282:9182-9194(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer."Jpn. J. Cancer Res. 89:825-828(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours."Oncogene 16:3083-3086(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations."Nucleic Acids Res. 27:4001-4007(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein."Nucleic Acids Res. 28:2672-2678(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer."DNA Repair 1:497-505(2002) [PubMed] [Europe PMC] [Abstract]