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Tumor Protein p73 (TP73)

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P73; p53-like transcription factor; p53-related protein

Tumor Protein p73 (TP73)
CCC C706
HGNC 12003
MGI 1336991
PubMed 20842728
RGD 1307083
UniProt O15350
Wiki TP73
p73 is a protein related to the p53 tumor protein. it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variants, and an alternative promoter in the DNA sequence.TP73 protein was the first identified homologue of the tumor suppressor gene, p53. Like p53, p73 has several variants. It is expressed as distinct forms differing at either at the C- or the N-terminus. Currently, six different C-terminus splicing variants have been found in normal cells. The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p73 (TP73) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p73 (TP73) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p73 (TP73) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p73 (TP73) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p73 (TP73) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p73 (TP73) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p73 (TP73) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p73 (TP73) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p73 (TP73) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p73 (TP73) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p73 (TP73) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p73 (TP73) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p73 (TP73) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p73 (TP73) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p73 (TP73) ELISA Kit Customized Service Offer
  1. "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers."Cell 90:809-819(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions."Genomics 51:359-363(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Two new p73 splice variants, gamma and delta, with different transcriptional activity."J. Exp. Med. 188:1763-1768(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta."Cell Death Differ. 6:389-390(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Mutational analysis of p73 and p53 in human cancer cell lines."Oncogene 18:3415-3421(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human DeltaNp73 regulates a dominant negative feedback loop for TAp73 and p53."Cell Death Differ. 8:1213-1223(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage."Nature 399:814-817(1999) [PubMed] [Europe PMC] [Abstract]
  11. ErratumNature 400:792-792(1999)
  12. "The emerging p53 gene family."J. Natl. Cancer Inst. 91:594-598(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif."J. Biol. Chem. 275:36316-36323(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Differential effect of ik3-1/cables on p53- and p73-induced cell death."J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo."J. Biol. Chem. 277:32020-32028(2002) [PubMed] [Europe PMC] [Abstract]
  16. "A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity."Biochem. Biophys. Res. Commun. 308:106-113(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Functional association between Wwox tumor suppressor protein and p73, a p53 homolog."Proc. Natl. Acad. Sci. U.S.A. 101:4401-4406(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells."Oncogene 24:938-944(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."J. Cell Biol. 172:589-604(2006) [PubMed] [Europe PMC] [Abstract]
  20. "p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1."Cell Cycle 7:1214-1223(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation."J. Biol. Chem. 283:8555-8563(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Regulation of p73 by Hck through kinase-dependent and independent mechanisms."BMC Mol. Biol. 8:45-45(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage."Mol. Cell 29:350-361(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation."Genes Cells 14:775-788(2009) [PubMed] [Europe PMC] [Abstract]
  25. "The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73."Oncogene 28:3157-3166(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination."Mol. Cancer Res. 9:1780-1790(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Epstein-Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor."Virology 448:333-343(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain."EMBO J. 18:4438-4445(1999) [PubMed] [Europe PMC] [Abstract]