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Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1)

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Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1)
CCC C707
HGNC 30032
MGI 1277113
PubMed 23159249
RGD 620579
UniProt Q6VY07
Wiki PACS1
Phosphofurin acidic cluster sorting protein 1 is a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain.
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  4. "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic."EMBO J. 20:2191-2201(2001) [PubMed] [Europe PMC] [Abstract]
  5. "HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes."Nat. Cell Biol. 2:163-167(2000) [PubMed] [Europe PMC] [Abstract]
  6. "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway."Cell 111:853-866(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia."EMBO J. 24:4415-4424(2005) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice."J. Biol. Chem. 283:11772-11784(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation."J. Virol. 86:9647-9655(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome."Am. J. Hum. Genet. 91:1122-1127(2012) [PubMed] [Europe PMC] [Abstract]