≡

Pantothenate Kinase 1 (PANK1)

[Edit]

PANK; PANK1a; PANK1b; hPanK1; Pantothenic acid kinase 1

Pantothenate Kinase 1 (PANK1)
CCC C711
HGNC 8598
MGI 1922985
PubMed 12095677
RGD 1304677
UniProt Q8TE04
Wiki PANK1
Pantothenate kinase 1 is a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.
Pantothenate kinase1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC711Hu01 Recombinant Pantothenate Kinase 1 (PANK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 1 (PANK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 1 (PANK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 1 (PANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 1 (PANK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC711Mu01 Recombinant Pantothenate Kinase 1 (PANK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC711Mu01 Polyclonal Antibody to Pantothenate Kinase 1 (PANK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pantothenate Kinase 1 (PANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 1 (PANK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pantothenate Kinase 1 (PANK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 1 (PANK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 1 (PANK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 1 (PANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 1 (PANK1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human pantothenate kinase gene."Int. J. Biochem. Cell Biol. 34:109-115(2002) [PubMed] [Europe PMC] [Abstract]
  2. "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression."J. Lipid Res. 45:17-31(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome."Nat. Genet. 28:345-349(2001) [PubMed] [Europe PMC] [Abstract]
  6. , Unpublished observations (JUL-2001)
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder."J. Biol. Chem. 282:27984-27993(2007) [PubMed] [Europe PMC] [Abstract]