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Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1)

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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1)
CCC C718
HGNC 8809
MGI 1926119
PubMed 22952425
RGD 69427
UniProt Q15118
Wiki PDK1
PDK1codes for an isozyme of pyruvate dehydrogenase kinase (PDK).The human PDK1 gene encodes a protein with a predicted molecular mass of 49,244 Da that shares 93% identity with that of the rat PDK1 gene. Northern blot analysis showed that the PDK1 message was expressed predominantly in the heart.
Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC718Hu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC718Hu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC718Mu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC718Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC718Ra01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC718Ra01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
MAC718Ra21 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
Assay Kits SEC718Ra ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells."J. Biol. Chem. 283:22700-22708(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer."Am. J. Pathol. 179:1405-1414(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism."Mol. Cell 44:864-877(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol."Structure 15:992-1004(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]