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Phosphoglucomutase 1 (PGM1)

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Glucose phosphomutase 1

Phosphoglucomutase 1 (PGM1)
CCC C723
HGNC 8905
MGI 97565
PubMed 9177117
RGD 3316
UniProt P36871
Wiki PGM1
Phosphoglucomutases (PGM) catalyze the transfer of phosphate between the 1 and 6 positions of glucose. Isozymes of PGM are monomeric, with molecular masses of about 60 kD, and are encoded by several genes, including PGM1. In most cell types, PGM1 isozymes predominate, representing about 90% of total PGM activity. One exception is red cells, where PGM2 is a major isozyme.Whitehouse et al. isolated a cDNA encoding human PGM1. Eighteen amino acid differences were found between human and rabbit PGM1. Southern blot analysis indicated that PGM1 is conserved among a wide variety of vertebrates ranging from primates to birds and amphibia. No evidence for PGM1-related sequences was found either by Southern blot analysis or by in situ hybridization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC723Hu01 Recombinant Phosphoglucomutase 1 (PGM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC723Hu01 Polyclonal Antibody to Phosphoglucomutase 1 (PGM1) WB,IHC
Assay Kits n/a CLIA Kit for Phosphoglucomutase 1 (PGM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 1 (PGM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoglucomutase 1 (PGM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoglucomutase 1 (PGM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoglucomutase 1 (PGM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoglucomutase 1 (PGM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 1 (PGM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoglucomutase 1 (PGM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoglucomutase 1 (PGM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoglucomutase 1 (PGM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoglucomutase 1 (PGM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 1 (PGM1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon."Biochem. J. 296:417-422(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase."Oncogene 23:8118-8127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Intragenic recombination at the human phosphoglucomutase 1 locus: predictions fulfilled."Proc. Natl. Acad. Sci. U.S.A. 90:10725-10729(1993) [PubMed] [Europe PMC] [Abstract]
  18. "The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination."Proc. Natl. Acad. Sci. U.S.A. 90:10730-10733(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Muscle glycogenosis due to phosphoglucomutase 1 deficiency."N. Engl. J. Med. 361:425-427(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Gene identification in the congenital disorders of glycosylation type I by whole-exome sequencing."Hum. Mol. Genet. 21:4151-4161(2012) [PubMed] [Europe PMC] [Abstract]
  21. "A novel congenital disorder of glycosylation type without central nervous system involvement caused by mutations in the phosphoglucomutase 1 gene."J. Inherit. Metab. Dis. 36:535-542(2013) [PubMed] [Europe PMC] [Abstract]
  22. "Multiple phenotypes in phosphoglucomutase 1 deficiency." N. Engl. J. Med. 370:533-542(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Compromised catalysis and potential folding defects in in vitro studies of missense mutants associated with hereditary phosphoglucomutase 1 deficiency."J. Biol. Chem. 289:32010-32019(2014) [PubMed] [Europe PMC] [Abstract]