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Phosphomannomutase 1 (PMM1)

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Sec53; PMMH-22; Brain Glucose-1,6-Bisphosphatase

Phosphomannomutase 1 (PMM1)
CCC C729
HGNC 9114
MGI 1353418
PubMed 16847318
RGD 1310897
UniProt Q92871
Wiki PMM1
Phosphomannomutase 1 is an enzyme encoded by the PMM1 gene.Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins.
The deduced 262-amino acid protein has a predicted molecular mass of 29 kD and shares 54% sequence identity with yeast phosphomannomutase. Expression of the human cDNA in Escherichia coli yielded an active phosphomannomutase that was purified to homogeneity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC729Hu01 Recombinant Phosphomannomutase 1 (PMM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC729Hu01 Polyclonal Antibody to Phosphomannomutase 1 (PMM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphomannomutase 1 (PMM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphomannomutase 1 (PMM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphomannomutase 1 (PMM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphomannomutase 1 (PMM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphomannomutase 1 (PMM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphomannomutase 1 (PMM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphomannomutase 1 (PMM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphomannomutase 1 (PMM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphomannomutase 1 (PMM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphomannomutase 1 (PMM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphomannomutase 1 (PMM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphomannomutase 1 (PMM1) ELISA Kit Customized Service Offer
  1. "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13."Genomics 40:41-47(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of the human phosphomannomutase gene (PMM1) and assignment to chromosome 22q13."Genomics 39:416-417(1997) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a."J. Biol. Chem. 281:14918-14926(2006) [PubMed] [Europe PMC] [Abstract]