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Proteasome Maturation Protein (POMP)

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PNAS-110; UMP1; Proteassemblin; Protein UMP1 homolog; Voltage-gated K channel beta subunit 4.1

Proteasome Maturation Protein (POMP)
CCC C731
HGNC 20330
MGI 1913787
PubMed 4515259
RGD 1305831
UniProt Q9Y244
Wiki POMP
Proteasome maturation protein is a short-lived maturation factor required for 20S proteasome subunit biogenesis. Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation.
Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i has been observed in Ref.11, but not in Ref.9. Forms tetramers. Ref.15

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC731Hu01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC731Hu01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB,IHC
Assay Kits n/a CLIA Kit for Proteasome Maturation Protein (POMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Maturation Protein (POMP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Maturation Protein (POMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Maturation Protein (POMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Maturation Protein (POMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Maturation Protein (POMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Maturation Protein (POMP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Maturation Protein (POMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Maturation Protein (POMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Maturation Protein (POMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Maturation Protein (POMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Maturation Protein (POMP) ELISA Kit Customized Service Offer
  1. "A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis."Am. J. Hum. Genet. 86:596-603(2010) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes."J. Mol. Biol. 301:1-9(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of proteassemblin, a mammalian homologue of the yeast protein, Ump1p, that is required for normal proteasome assembly."Mol. Cell Biol. Res. Commun. 3:212-217(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a mammalian protein interacting with 20S proteasome precursors."Proc. Natl. Acad. Sci. U.S.A. 97:10348-10353(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Protein-protein interactions among human 20S proteasome subunits and proteassemblin."Biochem. Biophys. Res. Commun. 314:523-528(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes."Nature 437:1381-1385(2005) [PubMed] [Europe PMC] [Abstract]
  11. "IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response."Proc. Natl. Acad. Sci. U.S.A. 102:9241-9246(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation."Int. J. Biol. Macromol. 38:259-267(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum."EMBO Rep. 8:1170-1175(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]