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Phosphoserine Phosphatase (PSPH)

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PSP; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase

Phosphoserine Phosphatase (PSPH)
CCC C736
HGNC 9577
MGI 97788
PubMed 15291819
RGD 1308764
UniProt P78330
Wiki PSPH
Phosphoserine phosphatase is an enzyme belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.
The 3 substrates of this enzyme are O-phospho-L-serine, O-phospho-D-serine, and H2O, whereas its 3 products are L-serine, D-serine, and phosphate.This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is O-phosphoserine phosphohydrolase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC736Hu01 Recombinant Phosphoserine Phosphatase (PSPH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC736Hu01 Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) WB; IHC; ICC; IP.
MAC736Hu21 Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) WB; IHC; ICC; IP.
Assay Kits SCC736Hu CLIA Kit for Phosphoserine Phosphatase (PSPH) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoserine Phosphatase (PSPH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoserine Phosphatase (PSPH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoserine Phosphatase (PSPH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoserine Phosphatase (PSPH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoserine Phosphatase (PSPH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoserine Phosphatase (PSPH) ELISA Kit Customized Service Offer
  1. "Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate."FEBS Lett. 408:281-284(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase."J. Biol. Chem. 277:46651-46658(2002) [PubMed] [Europe PMC] [Abstract]
  8. "High-resolution structure of human phosphoserine phosphatase in open conformation."Acta Crystallogr. D 59:971-977(2003) [PubMed] [Europe PMC] [Abstract]
  9. "How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase."Eur. J. Biochem. 271:3421-3427(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations responsible for 3-phosphoserine phosphatase deficiency."Eur. J. Hum. Genet. 12:163-166(2004) [PubMed] [Europe PMC] [Abstract]