Polypyrimidine Tract Binding Protein 1 (PTBP1)
[Edit]HNRNPI; HNRPI; PTB; PTB-T; PTB2; PTB3; PTB4; pPTB; Heterogeneous Nuclear Ribonucleoprotein I; 57 kDa RNA-binding protein PPTB-1
-92737.jpg)
Polypyrimidine tract-binding protein 1 is a protein belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC737Hu01 | Recombinant Polypyrimidine Tract Binding Protein 1 (PTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC737Hu01 | Polyclonal Antibody to Polypyrimidine Tract Binding Protein 1 (PTBP1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Polypyrimidine Tract Binding Protein 1 (PTBP1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Polypyrimidine Tract Binding Protein 1 (PTBP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Polypyrimidine Tract Binding Protein 1 (PTBP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Polypyrimidine Tract Binding Protein 1 (PTBP1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Polypyrimidine Tract Binding Protein 1 (PTBP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Polypyrimidine Tract Binding Protein 1 (PTBP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Polypyrimidine Tract Binding Protein 1 (PTBP1) | ELISA Kit Customized Service Offer |
- "Characterization of cDNAs encoding the polypyrimidine tract-binding protein."Genes Dev. 5:1224-1236(1991) [PubMed] [Europe PMC] [Abstract]
- "Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing."Genes Dev. 5:1237-1251(1991) [PubMed] [Europe PMC] [Abstract]
- "hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs."Nucleic Acids Res. 20:3671-3678(1992) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]