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Platelet Activating Factor Receptor (PAFR)

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PTAFR

Platelet Activating Factor Receptor (PAFR)
CCC C753
HGNC 9582
MGI 106066
PubMed 16721373
RGD 61897
UniProt P25105
Wiki PAFR
The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.The PAF receptor shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
PTAFR has 2 N-glycosylation sites, but unlike other rhodopsin family members, there is no N-glycosylation site in the N-terminal segment. Transfection of PTAFR into COS-7 cells resulted in expression of the receptor with an extracellular N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC753Hu01 Recombinant Platelet Activating Factor Receptor (PAFR) Positive Control; Immunogen; SDS-PAGE; WB.
CPC753Hu21 OVA Conjugated Platelet Activating Factor Receptor (PAFR) Immunogen; SDS-PAGE; WB.
Antibodies MAC753Hu21 Monoclonal Antibody to Platelet Activating Factor Receptor (PAFR) WB; IHC; ICC; IP.
PAC753Hu01 Polyclonal Antibody to Platelet Activating Factor Receptor (PAFR) WB; IHC; ICC; IP.
Assay Kits SEC753Hu ELISA Kit for Platelet Activating Factor Receptor (PAFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Activating Factor Receptor (PAFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Activating Factor Receptor (PAFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Activating Factor Receptor (PAFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Platelet Activating Factor Receptor (PAFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Activating Factor Receptor (PAFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet Activating Factor Receptor (PAFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Activating Factor Receptor (PAFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Activating Factor Receptor (PAFR) Polyclonal Antibody Customized Service Offer
Assay Kits SEC753Ra ELISA Kit for Platelet Activating Factor Receptor (PAFR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor."Biochem. Biophys. Res. Commun. 180:105-111(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog."J. Biol. Chem. 267:9101-9106(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1."Genomics 13:832-834(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart."Biochem. Biophys. Res. Commun. 189:617-624(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region."Am. J. Respir. Cell Mol. Biol. 8:240-244(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  11. ErratumNat. Genet. 23:373-373(1999)