≡

Plectin (PLEC)

[Edit]

HD1; PCN; EBS1; EBSO; PLEC1b; PLTN; Hemidesmosomal protein 1; Intermediate Filament Binding Protein 500kDa; Epidermolysis Bullosa Simplex 1(Ogna)

Plectin (PLEC)
CCC C754
HGNC 9069
MGI 1277961
PubMed 16507904
RGD 621649
UniProt Q6S380
Wiki Plectin
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes .
The plectin gene locus in mouse on chromosome 15 has been analyzed in detail , revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC754Hu01 Recombinant Plectin (PLEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC754Hu01 Polyclonal Antibody to Plectin (PLEC) WB; IHC; ICC; IP.
MAC754Hu22 Monoclonal Antibody to Plectin (PLEC) WB; IHC; ICC; IP.
Assay Kits SEC754Hu ELISA Kit for Plectin (PLEC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plectin (PLEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plectin (PLEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plectin (PLEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plectin (PLEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plectin (PLEC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plectin (PLEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plectin (PLEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plectin (PLEC) Polyclonal Antibody Customized Service Offer
Assay Kits SEC754Ra ELISA Kit for Plectin (PLEC) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24)."Proc. Natl. Acad. Sci. U.S.A. 93:4278-4283(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization."Genes Dev. 10:1724-1735(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]