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Proline Dehydrogenase, Mitochondrial (PRODH)

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PDH; PIG6; POX2; PRODH1; PRODH2; SCZD4; TP53I6; p53-induced gene 6 protein; L-Proline Dehydrogenase; L-Proline(acceptor)Oxidoreductase; Proline Oxidase 1

Proline Dehydrogenase, Mitochondrial (PRODH)
CCC C755
HGNC 9453
MGI 97770
PubMed 14618678
UniProt O43272
Wiki PRODH
Proline dehydrogenase, mitochondrial is a mitochondrial proline dehydrogenase which catalyzes the first step in proline catabolism. Deletion of this gene has been associated with type I hyperprolinemia. The gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes: DiGeorge syndrome and CATCH22 syndrome.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors.This enzyme participates in arginine and proline metabolism. the two substrates of this enzyme are L-proline and acceptor, whereas its two products are (S)-1-pyrroline-5-carboxylate and reduced acceptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC755Hu01 Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC755Hu01 Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC755Mu01 Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC755Mu01 Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) ELISA Kit Customized Service Offer
  1. "A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia."Hum. Genet. 101:69-74(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The gene encoding proline dehydrogenase modulates sensorimotor gating in mice."Nat. Genet. 21:434-439(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Functional consequences of PRODH missense mutations."Am. J. Hum. Genet. 76:409-420(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A model for p53-induced apoptosis."Nature 389:300-306(1997) [PubMed] [Europe PMC] [Abstract]
  7. "PRODH mutations and hyperprolinemia in a subset of schizophrenic patients."Hum. Mol. Genet. 11:2243-2249(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia."Proc. Natl. Acad. Sci. U.S.A. 99:3717-3722(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome." Hum. Mol. Genet. 16:83-91(2007) [PubMed] [Europe PMC] [Abstract]