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Poliovirus Receptor Related Protein 4 (PVRL4)

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PRR4; LNIR; Nectin-4; Ig superfamily receptor LNIR; Processed poliovirus receptor-related protein 4

Poliovirus Receptor Related Protein 4 (PVRL4)
CCC C757
HGNC 19688
MGI 1918990
PubMed 23682311
RGD 1559826
UniProt Q96NY8
Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001).
By database analysis, Reymond et al. (2001) identified the PVRL4 gene, which encodes a 510-amino acid protein with a predicted molecular mass of 55.5 kD. It contains 1 predicted transmembrane domain, followed by a 139-residue cytoplasmic sequence. Human and murine PVRL4 share 92% amino acid identity. Northern blot analysis showed strong expression of a 3.7-kb human PVRL4 transcript in placenta and weak expression in trachea. Murine Pvrl4 was expressed at embryonic days 11, 15 and 17. Immunohistochemistry revealed human PVRL4 localized to endothelial cells from vessels in placental villi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC757Hu01 Recombinant Poliovirus Receptor Related Protein 4 (PVRL4) Positive Control; Immunogen; SDS-PAGE; WB.
EPC757Hu61 Eukaryotic Poliovirus Receptor Related Protein 4 (PVRL4) Positive Control; Immunogen; SDS-PAGE; WB.
APC757Hu61 Active Poliovirus Receptor Related Protein 4 (PVRL4) Cell culture; Activity Assays.
Antibodies PAC757Hu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) WB; IHC; ICC; IP.
MAC757Hu22 Monoclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) WB; IHC; ICC; IP.
Assay Kits SEC757Hu ELISA Kit for Poliovirus Receptor Related Protein 4 (PVRL4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poliovirus Receptor Related Protein 4 (PVRL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poliovirus Receptor Related Protein 4 (PVRL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor Related Protein 4 (PVRL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poliovirus Receptor Related Protein 4 (PVRL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poliovirus Receptor Related Protein 4 (PVRL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poliovirus Receptor Related Protein 4 (PVRL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor Related Protein 4 (PVRL4) ELISA Kit Customized Service Offer
  1. "Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C'-D beta-strands of the nectin1 V domain."J. Biol. Chem. 277:27006-27013(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17."J. Biol. Chem. 280:19543-19550(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Nectin-4 is a new histological and serological tumor associated marker for breast cancer."BMC Cancer 7:73-73(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Adherens junction protein nectin-4 is the epithelial receptor for measles virus."Nature 480:530-533(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Nectin ectodomain structures reveal a canonical adhesive interface."Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4."Nat. Struct. Mol. Biol. 20:67-72(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome."Am. J. Hum. Genet. 87:265-273(2010) [PubMed] [Europe PMC] [Abstract]