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Retinaldehyde Binding Protein 1 (RLBP1)

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CRALBP; Cellular retinaldehyde-binding protein

Retinaldehyde Binding Protein 1 (RLBP1)
CCC C776
HGNC 10024
MGI 97930
PubMed 14718298
RGD 1309649
UniProt P12271
Wiki RLBP1
Retinaldehyde-binding protein 1 is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. CRALBP is not expressed in photoreceptors but is abundant in the retinal pigment epithelium (RPE) and Muller cells of the neuroretina, where it carries 11-cis-retinol and 11-cis-retinaldehyde. When expressed in bacteria, recombinant CRALBP containing the R150Q substitution was less soluble than wildtype recombinant CRALBP. Mutant CRALBP was purified and found to lack the ability to bind 11-cis-retinaldehyde.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC776Hu01 Recombinant Retinaldehyde Binding Protein 1 (RLBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC776Hu01 Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) WB; IHC; ICC; IP.
MAC776Hu21 Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) WB; IHC; ICC; IP.
Assay Kits SEC776Hu ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinaldehyde Binding Protein 1 (RLBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinaldehyde Binding Protein 1 (RLBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures."J. Biol. Chem. 263:18688-18692(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and structural analysis of the human gene encoding cellular retinaldehyde-binding protein."J. Biol. Chem. 269:25411-25418(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein."Protein Sci. 7:746-757(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Newfoundland rod-cone dystrophy, an early-onset retinal dystrophy, is caused by splice-junction mutations in RLBP1."Am. J. Hum. Genet. 70:955-964(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W."Proc. Natl. Acad. Sci. U.S.A. 106:18545-18550(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa."Nat. Genet. 17:198-200(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Bothnia dystrophy caused by mutations in the cellular retinaldehyde-binding protein gene (RLBP1) on chromosome 15q26."Invest. Ophthalmol. Vis. Sci. 40:995-1000(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Recessive mutations in the RLBP1 gene encoding cellular retinaldehyde-binding protein in a form of retinitis punctata albescens."Invest. Ophthalmol. Vis. Sci. 40:1000-1004(1999) [PubMed] [Europe PMC] [Abstract]