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T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1)

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T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1)
CCC C778
HGNC 11805
MGI 103306
PubMed 12829230
RGD 1307455
UniProt Q13009
Wiki TIAM1
TIAM1 is a human protein modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of Rho-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
It is tightly associate with BAIAP2 as a subunit. It was found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC778Hu01 Recombinant T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC778Hu01 Polyclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1) ELISA Kit Customized Service Offer
  1. "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin."Oncogene 10:1371-1376(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A role for Rac in Tiam1-induced membrane ruffling and invasion."Nature 375:338-340(1995) [PubMed] [Europe PMC] [Abstract]
  5. "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16."Cytogenet. Cell Genet. 70:48-51(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation."Mol. Cell. Biol. 25:4602-4614(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "CCM1 regulates vascular-lumen organization by inducing endothelial polarity."J. Cell Sci. 123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract]
  11. "EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor."Mol. Cells 29:603-609(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the PDZ domain of T-cell lymphoma invasion and metastasis 1 variant."Submitted (JUN-2006) to the PDB data bank
  14. "The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion."J. Mol. Biol. 398:730-746(2010) [PubMed] [Europe PMC] [Abstract]
  15. "High-resolution structure of the Tiam1 PHn-CC-Ex domain."Acta Crystallogr. F 69:744-752(2013) [PubMed] [Europe PMC] [Abstract]
  16. "The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics."Structure 21:342-354(2013) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia."Am. J. Hum. Genet. 89:745-750(2011) [PubMed] [Europe PMC] [Abstract]